Stress is not seductive—it disrupts sex hormones, dries up juicier inclinations, and affects your sexual satisfaction.
| Preference | Explanation | Examples |
|---|---|---|
| Natural Ingredients | Desire for organic, herbal options | DesireX, FemmeBoost |
| Fast Results | Prefers quick improvements | Synthetic options, some OTC pills |
| Minimal Side Effects | Focus on safety and tolerability | Herbal-based tinctures or supplements |
| Price Affordability | Cost-effective products | Many OTC supplements |
If we fall under the wave of everyday pressures, we not only hamper our ability to connect with one another, we compromise the flow that contributes to healthy fertility, virility, creativity, and feelings of fulfillment. Sex Dust® is a natural libido supplement that brings together a potent blend of adaptogens and herbs that target stress to support hormonal balance, desire, sexual arousal, and creative energy. Get to know the stimulating ingredients in this libido supplement: Shatavari – This powerful plant from the asparagus family is traditionally used as an ingredient in Traditional Chinese Medicine to support healthy hormonal balance through each phase of life, from PMS to menopause. Shilajit – This mineral-rich resin is traditionally used to balance systems throughout the body and can optimize testosterone, cultivating increased sexual arousal. Epimedium – Also known as Horny Goat Weed, this flowering plant is an active ingredient traditionally used to help ignite sexual desire and sensation by boosting libido. Schisandra – Priced in Traditional Chinese Medicine as a longevity and beauty berry, this ingredient is known for its ability to increase blood flow and energy. Whether you’re looking for hormonal support, want to boost libido with a natural sex health supplement, or reclaim your sex life, spike your daily coffee or tea with Sex Dust® to support your sexual wellness. For years, phosphodiesterase type fildena tablet 5 inhibitors have been used for the treatment of erectile dysfunctions. Due to the similarities between male and female sexual response, several studies have assessed the effects of sildenafil citrate (Viagra®) in women affected by female sexual arousal disorder. The results are still conflicting and the drug is not devoid of adverse effects. Furthermore, female sexual arousal disorder is a heterogeneous condition whose underlying causes are difficult to diagnose and appropriate treatment requires a thorough sexual, psychological, and medical history along with specialist consultations. The clinician should pursue a global approach to the patient with sexual difficulties, while non-hormonal treatment such as phosphodiesterase type 5 inhibitors (ie, sildenafil citrate) should be kept as the last option. Keywords: phosphodiesterase type 5 inhibitors, female sexual arousal disorder (FSAD), sildenafil citrate In clinical practice, not only gynecologists but also generalists are often asked to solve specific questions about sexual diseases. According to recent estimates, sexual dysfunction has occurred in 40%–45% of women and 20%–30% of men at least once in their lifetime.1 For years, studies have focused mainly on erectile dysfunction while female sexual disorders (FSDs), although more frequent than male sexual disturbances, have been hardly considered.2 Even general practitioners are used to dealing with male sexual dysfunction and often prescribe easily available drugs such as sildenafil citrate (Viagra®). On the contrary, women have begun to complain about sexual troubles only recently and have caught their doctors off-guard.
How should FSD be diagnosed and treated? A more thorough understanding of female sexual problems is needed to ensure appropriate clinical management of sexual difficulties. The Diagnostic and Statistical Manual of Mental Disorder, Fifth Edition (DSM-V)2 defines FSDs as disturbances in the female sexual response cycle, resulting in marked distress and interpersonal difficulties. In particular, female sexual arousal disorder (FSAD) belongs to the so-called “female sexual interest/arousal disorder” and is one of the most prevalent subcategories of FSDs.
FSAD is traditionally defined as a persistent or recurrent inability to attain or maintain adequate lubrication and genital swelling until completion of sexual activity.3 Such a clinical condition may depend either on local or general factors. In fact, genital congestion and lubrication strictly depend on the hormonal balance (ie, arousal disorders during the menopausal transition) and require adequate vascular function and an efficient nerve transmission of mechanical stimuli.4 Thus, iatrogenic factors (eg, chronic antidepressant treatments, surgical procedures, radiotherapy of the pelvis), along with endocrine, vascular, and neurological disorders can cause female sexual dysfunction. However, a modern definition of FSDs should not focus only on genital phenomena without considering the psychological aspect of arousal.
Stress is not seductive—it disrupts sex hormones, dries up juicier inclinations, and affects your sexual satisfaction. If we fall under the wave of everyday pressures, we not only hamper our ability to connect with one another, we compromise the flow that contributes to healthy fertility, virility, creativity, and feelings of fulfillment. Sex Dust® is a natural libido supplement that brings together a potent blend of adaptogens and herbs that target stress to support hormonal balance, desire, sexual arousal, and creative energy. Get to know the stimulating ingredients in this libido supplement: Shatavari – This powerful plant from the asparagus family is traditionally used as an ingredient in Traditional Chinese Medicine to support healthy hormonal balance through each phase of life, from PMS to menopause. Shilajit – This mineral-rich resin is traditionally used to balance systems throughout the body and can optimize testosterone, cultivating increased sexual arousal.
Epimedium – Also known as Horny Goat Weed, this flowering plant is an active ingredient traditionally used to help ignite sexual desire and sensation by boosting libido. Schisandra – Priced in Traditional Chinese Medicine as a longevity and beauty berry, this ingredient is known for its ability to increase blood flow and energy. Whether you’re looking for hormonal support, want to boost libido with a natural sex health supplement, or reclaim your sex life, spike your daily coffee or tea with Sex Dust® to support your sexual wellness. For years, phosphodiesterase type fildena tablet 5 inhibitors have been used for the treatment of erectile dysfunctions. Due to the similarities between male and female sexual response, several studies have assessed the effects of sildenafil citrate (Viagra®) in women affected by female sexual arousal disorder.
The results are still conflicting and the drug is not devoid of adverse effects. Furthermore, female sexual arousal disorder is a heterogeneous condition whose underlying causes are difficult to diagnose and appropriate treatment requires a thorough sexual, psychological, and medical history along with specialist consultations. The clinician should pursue a global approach to the patient with sexual difficulties, while non-hormonal treatment such as phosphodiesterase type 5 inhibitors (ie, sildenafil citrate) should be kept as the last option. Keywords: phosphodiesterase type 5 inhibitors, female sexual arousal disorder (FSAD), sildenafil citrate In clinical practice, not only gynecologists but also generalists are often asked to solve specific questions about sexual diseases. According to recent estimates, sexual dysfunction has occurred in 40%–45% of women and 20%–30% of men at least once in their lifetime.1 For years, studies have focused mainly on erectile dysfunction while female sexual disorders (FSDs), although more frequent than male sexual disturbances, have been hardly considered.2 Even general practitioners are used to dealing with male sexual dysfunction and often prescribe easily available drugs such as sildenafil citrate (Viagra®). In fact, women very often relate arousal to the subjective feeling of been “sexually involved” more than to the super p force online physiological response to erotic stimuli (ie, vaginal lubrication and engorgement of sexual tissues such as nipples, vulva, clitoris, and vaginal walls). Thus, such factors as sexual inhibition, depression or anxiety, inadequate sexual stimulation, or interpersonal problems may impair women’s arousal.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Effervescent Tablets | 100 mg | 84 + 7 Pills | 202.91€ 193.25€ | |
| Cialis Generic | 10mg | 10 Pills | 31.41€ 29.91€ | |
| Viagra Generic | 150mg | 180 + 10 Pills | 236.46€ 225.20€ | |
| Viagra Generic | 100mg | 360 + 10 Pills | 330.21€ 314.49€ | |
| Kamagra Effervescent Tablets | 100 mg | 28 Pills | 90.83€ 86.50€ | |
| Cialis Generic | 5mg | 60 + 4 Pills | 86.02€ 81.92€ | |
| Kamagra Soft Tabs | 100 mg | 180 + 8 Pills | 425.45€ 405.19€ | |
| Levitra Generic | 20mg | 360 + 10 Pills | 458.44€ 436.61€ | |
| Super Kamagra | 160 mg | 12 Pills | 101.10€ 96.29€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ | |
| Cialis Generic | 60mg | 20 Pills | 65.61€ 62.49€ | |
| Kamagra Polo | 100mg | 180 + 8 Pills | 446.52€ 425.26€ | |
| Kamagra Oral Jelly | 100 mg | 90 + 8 Sachets | 303.56€ 289.10€ | |
| Cialis Professional | 40mg | 30 Pills | 148.94€ 141.85€ | |
| Viagra Professional | 100mg | 30 Pills | 88.92€ 84.69€ | |
| Viagra Professional | 100mg | 20 Pills | 71.14€ 67.75€ | |
| Cialis Black | 80mg | 10 Pills | 43.27€ 41.21€ |
Moreover, FSADs are frequently associated with other FSDs concerning desire, orgasm, and pain.4 To sum up, Basson et al5 categorized FSAD into three main classes: subjective, genital, and combined (Table 1). In subjective FSAD, the woman’s emotional response to sexual stimuli is altered but the physical response still occurs, while genital phenomena are impaired in objective FSAD. However, in most cases, both factors contribute to FSAD (combined). In smooth muscle cells, nitric oxide activates the guanylate cyclase enzyme which converts guanosine triphosphate into cyclic guanosine monophosphate. This molecule promotes the relaxation of the smooth muscle cells, causes vasodilatation, and increases blood flow in genital organs.
Van der Made et al examined the efficacy of vardenafil alone or combined with testosterone in 28 women affected by FSADs and/or hypoactive sexual desire disorder. The combination of testosterone and vardenafil caused an improvement in genital response (ie, vaginal pulse amplitude at vaginal photoplethysmography), especially in a group that initially had low attention for sexual cues.15 The efficacy of tadalafil was evaluated in 33 type 1 premenopausal diabetic women affected by sexual genital arousal disorder. A daily dose of tadalafil 5 mg treatment seemed to improve subjective sexual aspects. It was suggested that this treatment may be effective in improving clitoral blood flow as well as the clitoral functional system, consisting of smooth muscle cells and vascular spaces.16 There are a few things that a generalist should bear in mind when addressing a woman with FSAD.
The engorgement of penile corpora cavernosa in men and clitoris and labia minora in women are the main modifications of genital organs during sexual arousal. Furthermore, the ultrafiltration of plasma through capillary vaginal vessels contributes to vaginal lubrication.6 Phosphodiesterase type 5 (PDE5) inhibitors (eg, sildenafil, tadalafil, vardenafil) physiologically enhance the production of guanosine monophosphate from cyclic guanosine monophosphate, thus contrasting the above-mentioned effects (Figure 1).
According to emerging data, PDE5 is expressed in vaginal, clitoral, and labial smooth muscles.
On the contrary, women have begun to complain about sexual troubles only recently and have caught their doctors off-guard. How should FSD be diagnosed and treated? A more thorough understanding of female sexual problems is needed to ensure appropriate clinical management of sexual difficulties. The Diagnostic and Statistical Manual of Mental Disorder, Fifth Edition (DSM-V)2 defines FSDs as disturbances in the female sexual response cycle, resulting in marked distress and interpersonal difficulties. In particular, female sexual arousal disorder (FSAD) belongs to the so-called “female sexual interest/arousal disorder” and is one of the most prevalent subcategories of FSDs.
FSAD is traditionally defined as a persistent or recurrent inability to attain or maintain adequate lubrication and genital swelling until completion of sexual activity.3 Such a clinical condition may depend either on local or general factors. In fact, genital congestion and lubrication strictly depend on the hormonal balance (ie, arousal disorders during the menopausal transition) and require adequate vascular function and an efficient nerve transmission of mechanical stimuli.4 Thus, iatrogenic factors (eg, chronic antidepressant treatments, surgical procedures, radiotherapy of the pelvis), along with endocrine, vascular, and neurological disorders can cause female sexual dysfunction. However, a modern definition of FSDs should not focus only on genital phenomena without considering the psychological aspect of arousal. In fact, women very often relate arousal to the subjective feeling of been “sexually involved” more than to the super p force online physiological response to erotic stimuli (ie, vaginal lubrication and engorgement of sexual tissues such as nipples, vulva, clitoris, and vaginal walls). Thus, such factors as sexual inhibition, depression or anxiety, inadequate sexual stimulation, or interpersonal problems may impair women’s arousal.
Moreover, FSADs are frequently associated with other FSDs concerning desire, orgasm, and pain.4 To sum up, Basson et al5 categorized FSAD into three main classes: subjective, genital, and combined (Table 1). In subjective FSAD, the woman’s emotional response to sexual stimuli is altered but the physical response still occurs, while genital phenomena are impaired in objective FSAD. However, in most cases, both factors contribute to FSAD (combined). In smooth muscle cells, nitric oxide activates the guanylate cyclase enzyme which converts guanosine triphosphate into cyclic guanosine monophosphate. This molecule promotes the relaxation of the smooth muscle cells, causes vasodilatation, and increases blood flow in genital organs. Thus, PDE5 inhibitors could be used as an easily available medical treatment for genital FSADs.7 Sildenafil citrate (Viagra), a PDE5 ed treatment drugs inhibitor, has been successfully used for the treatment of male erectile dysfunction since the late 1990s.8 The analogies between male and female physiological response to sexual stimuli have prompted studies over its efficacy in FSAD. However, there are presently very few data regarding the use of sildenafil in women and the results are still conflicting. In a randomized double-blind study, Berman et al administered sildenafil to 202 postmenopausal women with a primary diagnosis of FSAD and possibly associated secondary FSDs. Patients randomly received 12 weeks of treatment with sildenafil citrate 50 mg or placebo. A significant improvement of arousal sensation, lubrication, and orgasm was reported in the study group affected by primary FSAD. On the contrary, women affected by different types of FSDs (eg, hypoactive sexual disorder, dyspareunia due to vaginal dryness) did not experience any significant improvement in desire, pain, or enjoyment.9 In all the studies confirming the positive results of sildenafil, the drug proved to be more effective in the genital subgroup. It can be speculated that sildenafil citrate only acts on the physical phenomena of arousal and does not completely respond to the complexity of FSAD.
In fact, encouraging results were achieved in specific groups of patients affected by secondary FSADs (eg, diabetes mellitus, multiple sclerosis, chronic antidepressant users) in which the genital arousal disorder is clearly connected with a neurological or vascular injury.10–12 However, negative results are also reported in literature.
Firstly, women affected by FSADs do not benefit from sildenafil citrate as much as men with erectile dysfunction as a result of a lower concentration of PDE5 in vaginal and clitoral tissues than in penile corpora cavernosa.7 Secondly, a randomized double-blind study including both pre- and postmenopausal women did not show any success from sildenafil citrate treatment.
The engorgement of penile corpora cavernosa in men and clitoris and labia minora in women are the main modifications of genital organs during sexual arousal. Furthermore, the ultrafiltration of plasma through capillary vaginal vessels contributes to vaginal lubrication.6 Phosphodiesterase type 5 (PDE5) inhibitors (eg, sildenafil, tadalafil, vardenafil) physiologically enhance the production of guanosine monophosphate from cyclic guanosine monophosphate, thus contrasting the above-mentioned effects (Figure 1). According to emerging data, PDE5 is expressed in vaginal, clitoral, and labial smooth muscles. Thus, PDE5 inhibitors could be used as an easily available medical treatment for genital FSADs.7 Sildenafil citrate (Viagra), a PDE5 ed treatment drugs inhibitor, has been successfully used for the treatment of male erectile dysfunction since the late 1990s.8 The analogies between male and female physiological response to sexual stimuli have prompted studies over its efficacy in FSAD. However, there are presently very few data regarding the use of sildenafil in women and the results are still conflicting.
In a randomized double-blind study, Berman et al administered sildenafil to 202 postmenopausal women with a primary diagnosis of FSAD and possibly associated secondary FSDs. Patients randomly received 12 weeks of treatment with sildenafil citrate 50 mg or placebo. A significant improvement of arousal sensation, lubrication, and orgasm was reported in the study group affected by primary FSAD. On the contrary, women affected by different types of FSDs (eg, hypoactive sexual disorder, dyspareunia due to vaginal dryness) did not experience any significant improvement in desire, pain, or enjoyment.9 In all the studies confirming the positive results of sildenafil, the drug proved to be more effective in the genital subgroup. It can be speculated that sildenafil citrate only acts on the physical phenomena of arousal and does not completely respond to the complexity of FSAD.
In fact, encouraging results were achieved in specific groups of patients affected by secondary FSADs (eg, diabetes mellitus, multiple sclerosis, chronic antidepressant users) in which the genital arousal disorder is clearly connected with a neurological or vascular injury.10–12 However, negative results are also reported in literature. Firstly, women affected by FSADs do not benefit from sildenafil citrate as much as men with erectile dysfunction as a result of a lower concentration of PDE5 in vaginal and clitoral tissues than in penile corpora cavernosa.7 Secondly, a randomized double-blind study including both pre- and postmenopausal women did not show any success from sildenafil citrate treatment. In fact, no significant changes in physical response during sexual activity were reported in either group of women.13 It should also be considered that sildenafil citrate is not devoid of side effects. The most common adverse events reported in all studies were headache, flushing, nausea, rhinitis, and visual disturbances.14 In addition, sildenafil is strictly contraindicated in patients using oral or transdermal nitrates, as it dangerously potentiates the hypotensive effect of these drugs.8 Due to these major drawbacks as well as to the lack of conclusive results, non-hormonal treatments for FSAD have not been approved yet. Only a few studies have evaluated the role of other PDE5 inhibitors in FSADs. In fact, no significant changes in physical response during sexual activity were reported in either group of women.13 It should also be considered that sildenafil citrate is not devoid of side effects. The most common adverse events reported in all studies were headache, flushing, nausea, rhinitis, and visual disturbances.14 In addition, sildenafil is strictly contraindicated in patients using oral or transdermal nitrates, as it dangerously potentiates the hypotensive effect of these drugs.8 Due to these major drawbacks as well as to the lack of conclusive results, non-hormonal treatments for FSAD have not been approved yet.
| Risk | Possible Cause | Prevention Measures |
|---|---|---|
| Interactions with Medications | Herbal ingredients affecting drug metabolism | Consult a healthcare provider |
| Overdose | Excessive dosing or multiple products simultaneously | Follow dosing instructions strictly |
| Dependency or Psychological Dependence | Reliance on pills for arousal | Use as part of a healthy sexual routine |
| Mislabeled or Contaminated Products | Lack of regulation, counterfeit products | Purchase from reputable sources |
Only a few studies have evaluated the role of other PDE5 inhibitors in FSADs.
Van der Made et al examined the efficacy of vardenafil alone or combined with testosterone in 28 women affected by FSADs and/or hypoactive sexual desire disorder. The combination of testosterone and vardenafil caused an improvement in genital response (ie, vaginal pulse amplitude at vaginal photoplethysmography), especially in a group that initially had low attention for sexual cues.15 The efficacy of tadalafil was evaluated in 33 type 1 premenopausal diabetic women affected by sexual genital arousal disorder. A daily dose of tadalafil 5 mg treatment seemed to improve subjective sexual aspects. It was suggested that this treatment may be effective in improving clitoral blood flow as well as the clitoral functional system, consisting of smooth muscle cells and vascular spaces.16 There are a few things that a generalist should bear in mind when addressing a woman with FSAD.