Similarly, these medicinal/herbal products should not be administered within 7 days after this medicine has been discontinued. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Contraindications Concomitant treatment of potent CYP3A4 inhibitors such as Ketoconazole, Itraconazole, Ritonavir, Saquinavir, Telithromycin, Nefazadone, Nelfinavir, Atazanavir, etc.
Do not use Tadalafil Dapoxetine tablets in patients who are using a GC stimulator, such as Riociguat. Tadalafil may potentiate the hypotensive effects of GC stimulators. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Storage Instructions Tadalafil Dapoxetine Tablets have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients should not use Tadalafil Dapoxetine tablets if sex is inadvisable due to cardiovascular status. Use of Tadalafil Dapoxetine tablets with alpha blockers, antihypertensives or substantial amounts of alcohol (5 units or greater) may lead to hypotension. This medicine is not recommended in combination with alpha blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering. Caution is advised when Tadalafil Dapoxetine tablets are used as a treatment for ED in men taking alpha blockers. Tadalafil Dapoxetine tablets are not suitable and should not be used if taking potent inhibitors of CYP3A4. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients should seek emergency treatment if an erection lasts for more than 4 hours. Use Tadalafil Dapoxetine tablets with caution in patients predisposed to priapism. Patients should stop Tadalafil Dapoxetine tablets and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of Non Arteritic Ischemic Optic Neuropathy (NAION).
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Polo | 100 mg | 84 + 4 Pills | 244.49€ 232.85€ | |
| Priligy Generic Dapoxetine | 60mg | 10 Pills | 47.63€ 45.36€ | |
| Priligy Generic Dapoxetine | 60mg | 180 + 10 Pills | 494.76€ 471.20€ | |
| Levitra Professional | 20mg | 120 + 4 Pills | 348.44€ 331.85€ | |
| Viagra Generic | 50mg | 60 + 4 Pills | 83.93€ 79.93€ | |
| Priligy Generic Dapoxetine | 60mg | 120 + 10 Pills | 341.26€ 325.01€ | |
| Viagra Generic | 50mg | 270 + 8 Pills | 198.48€ 189.03€ | |
| Apcalis SX Oral Jelly | 20mg | 10 Sachets | 58.75€ 55.95€ | |
| Kamagra Oral Jelly | 100mg | 30 + 5 Sachets | 136.20€ 129.71€ | |
| Priligy Generic Dapoxetine | 60mg | 20 + 4 Pills | 77.31€ 73.63€ | |
| Cialis Soft Tabs | 20mg | 30 + 4 Pills | 87.43€ 83.27€ | |
| Viagra Oral Jelly | 100mg | 10 Sachets | 46.36€ 44.15€ | |
| Priligy Generic Dapoxetine | 60mg | 90 + 10 Pills | 265.64€ 252.99€ | |
| Priligy Generic Dapoxetine | 60mg | 60 + 8 Pills | 183.06€ 174.34€ | |
| Priligy Generic Dapoxetine | 60mg | 30 + 6 Pills | 106.65€ 101.57€ | |
| Kamagra Gold | 50 mg | 60 + 4 Pills | 171.14€ 162.99€ | |
| Super Kamagra | 160 mg | 8 Pills | 69.23€ 65.93€ |
Discuss increased risk of NAION in patients with history of NAION. Patients should dapoxetine 60 mg tablets stop Tadalafil Dapoxetine tablets and seek prompt medical attention in the event of sudden decrease or loss of hearing. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Dapoxetine, a constituent of this medicine is only indicated in men with Premature Ejaculation who meet all the criteria listed listed earlier.
© Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Possible Side Effects Most common side effects Tadalafil Dapoxetine Combination tablets are increased thirst and a light-headedness following sudden movements - this is natural, as blood moves into the genital areas. The common side effects include headache, dyspepsia, back pain, myalgia, nasal congestion, flushing, nausea, dizziness, diarrhoea, insomnia,fatigue and pain in limb. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets Overdose Single doses up to 500 mg of Tadalafil have been given to healthy subjects, and multiple daily doses up to 100 mg have been given to patients. Adverse events were similar to those seen at lower doses. In cases of overdose, standard supportive measures should be adopted as required.
© Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets Overdose No case of Dapoxetine overdose has been reported. There were no unexpected adverse events in a clinical pharmacology study of Dapoxetine with daily doses up to 240 mg (two 120 mg doses given 3 hours apart). In general, symptoms of overdose with SSRIs include serotonin-mediated adverse reactions such as somnolence, gastrointestinal disturbances such as nausea and vomiting, tachycardia, tremor, agitation and dizziness. Due to high protein binding and large volume of distribution of Dapoxetine Hydrochloride, forced diuresis, dialysis, hemoperfusion and exchange transfusion are unlikely to be of benefit.
Dapoxetine should not be prescribed to men who have not been diagnosed with Premature Ejaculation. Safety has not been established and there are no data on the ejaculation-delaying effects in men without Premature Ejaculation.
| Effect Parameter | Dapoxetine | Tadalafil |
|---|---|---|
| Onset of Action | Within 1 hour | Within 30 minutes to 2 hours |
| Duration of Effect | About 3 hours | Up to 36 hours |
| Success Rate in Erectile Dysfunction | Low (not primary use) | High (75-80%) |
| Success Rate in Premature Ejaculation | High | Not effective for this purpose |
Before treatment initiation, a careful medical examination including history of orthostatic events should be performed by the physician. An orthostatic test should be performed before initiating therapy (blood pressure and pulse rate, supine and standing). In case of a history of documented or suspected orthostatic reaction, treatment with Tadalafil Dapoxetine tablets should be avoided. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Antidepressants, including SSRIs, increased the risk compared to placebo of suicidal thinking and suicidality in short-term studies in children and adolescents with Major Depressive Disorder and other psychiatric disorders. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24. In clinical trials with Dapoxetine, a constituent of Tadalafil Dapoxetine tablets for the treatment of premature ejaculation, there was no clear indication of treatment-emergent suicidality in evaluation of possibly suicide-related adverse events.
Patients should avoid operating hazardous machinery, should syncope or its prodromal symptoms such as dizziness or lightheadedness occur.
The risk of adverse cardiovascular outcomes from syncope (cardiac syncope and syncope from other causes) is increased in patients with underlying structural cardiovascular disease. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients should be advised not to use Tadalafil Dapoxetine tablets in combination with recreational drugs. Patients should be advised not to use Tadalafil Dapoxetine tablets in combination with alcohol. Combining alcohol with dapoxetine may increase alcohol-related neurocognitive effects and may also enhance neurocardiogenic adverse events such as syncope, thereby increasing the risk of accidental injury; therefore, patients should be advised to avoid alcohol while taking Tadalafil Dapoxetine tablets .
Tadalafil Dapoxetine tablets should be prescribed with caution in patients taking medicinal products with vasodilatation properties (such as alpha adrenergic receptor antagonists and nitrates) due to possible reduced orthostatic tolerance.
| Parameter | Dapoxetine | Tadalafil |
|---|---|---|
| Absorption | Rapid; peak in 1-3 hours | Peak in 2 hours |
| Bioavailability | Approximately 54% | About 84% |
| Metabolism | Liver via CYP2D6 & CYP3A4 | Liver via CYP3A4 |
| Half-life | 1-1.5 hours | 17.5 hours |
| Excretion | Urine and feces | Mainly feces |
© Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings This medicine is not suitable in patients taking moderate CYP3A4 inhibitors and in patients taking potent CYP2D6 inhibitors since the Dapoxetine dose is restricted to 30 mg. Tadalafil Dapoxetine tablets should not be used in patients with a history of mania/hypomania or bipolar disorder and should be discontinued in any patient who develops symptoms of these disorders. Due to the potential of SSRIs to lower the seizure threshold, Tadalafil Dapoxetine tablets should be discontinued in any patient who develops seizures and avoided in patients with unstable epilepsy. Patients with controlled epilepsy should be carefully monitored. Tadalafil Dapoxetine tablets should not be used in individuals below 18 years of age. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Tadalafil Dapoxetine tablets are not indicated for psychiatric disorders and should not be used in men with these disorders, such as schizophrenia, or in those suffering with co-morbid depression, as worsening of symptoms associated with depression cannot be excluded. There have been reports of bleeding abnormalities with SSRIs. Caution is advised in patients taking this medicine, particularly in concomitant use with medicinal products known to affect platelet function or anticoagulants, as well as vardenafil with dapoxetine tablets in patients with a history of bleeding or coagulation disorders.
Combining alcohol with dapoxetine may increase alcohol-related neurocognitive effects and may also enhance neurocardiogenic adverse events such as syncope, thereby increasing the risk of accidental injury; therefore, patients should be advised to avoid alcohol while taking Tadalafil Dapoxetine tablets . Tadalafil Dapoxetine tablets should be prescribed with caution in patients taking medicinal products with vasodilatation properties (such as alpha adrenergic receptor antagonists and nitrates) due to possible reduced orthostatic tolerance. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings This medicine is not suitable in patients taking moderate CYP3A4 inhibitors and in patients taking potent CYP2D6 inhibitors since the Dapoxetine dose is restricted to 30 mg. Tadalafil Dapoxetine tablets should not be used in patients with a history of mania/hypomania or bipolar disorder and should be discontinued in any patient who develops symptoms of these disorders. Due to the potential of SSRIs to lower the seizure threshold, Tadalafil Dapoxetine tablets should be discontinued in any patient who develops seizures and avoided in patients with unstable epilepsy.
Patients with controlled epilepsy should be carefully monitored. Tadalafil Dapoxetine tablets should not be used in individuals below 18 years of age. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Tadalafil Dapoxetine tablets are not indicated for psychiatric disorders and should not be used in men with these disorders, such as schizophrenia, or in those suffering with co-morbid depression, as worsening of symptoms associated with depression cannot be excluded. There have been reports of bleeding abnormalities with SSRIs. Caution is advised in patients taking this medicine, particularly in concomitant use with medicinal products known to affect platelet function or anticoagulants, as well as vardenafil with dapoxetine tablets in patients with a history of bleeding or coagulation disorders.
Tadalafil Dapoxetine tablets are not recommended for use in patients with severe renal impairment and caution is advised in patients with mild or moderate renal impairment. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this Tadalafil Dapoxetine tablets. The use of Dapoxetine, a constituent of Tadalafil Dapoxetine tablets has been associated with ocular effects such as mydriasis and eye pain. Dapoxetine should be used with caution in patients with raised intraocular pressure or those at risk of angle closure glaucoma. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Withdrawal Effects Abrupt discontinuation of chronically administered SSRIs used to treat chronic depressive disorders has been reported to result in the following symptoms: dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesias such as electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia and hypomania. Tadalafil Dapoxetine tablets are not recommended for use in patients with severe renal impairment and caution is advised in patients with mild or moderate renal impairment. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this Tadalafil Dapoxetine tablets. The use of Dapoxetine, a constituent of Tadalafil Dapoxetine tablets has been associated with ocular effects such as mydriasis and eye pain.
Similarly, these medicinal/herbal products should not be administered within 7 days after this medicine has been discontinued. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Contraindications Concomitant treatment of potent CYP3A4 inhibitors such as Ketoconazole, Itraconazole, Ritonavir, Saquinavir, Telithromycin, Nefazadone, Nelfinavir, Atazanavir, etc. Do not use Tadalafil Dapoxetine tablets in patients who are using a GC stimulator, such as Riociguat. Tadalafil may potentiate the hypotensive effects of GC stimulators. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Storage Instructions Tadalafil Dapoxetine Tablets have to be stored at controlled room temperature i.e.
from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients should not use Tadalafil Dapoxetine tablets if sex is inadvisable due to cardiovascular status. Use of Tadalafil Dapoxetine tablets with alpha blockers, antihypertensives or substantial amounts of alcohol (5 units or greater) may lead to hypotension. This medicine is not recommended in combination with alpha blockers for the treatment of BPH because efficacy of the combination has not been adequately studied and because of the risk of blood pressure lowering.
Caution is advised when Tadalafil Dapoxetine tablets are used as a treatment for ED in men taking alpha blockers. Tadalafil Dapoxetine tablets are not suitable and should not be used if taking potent inhibitors of CYP3A4. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients should seek emergency treatment if an erection lasts for more than 4 hours. Use Tadalafil Dapoxetine tablets with caution in patients predisposed to priapism. Patients should stop Tadalafil Dapoxetine tablets and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of Non Arteritic Ischemic Optic Neuropathy (NAION). Dapoxetine should be used with caution in patients with raised intraocular pressure or those at risk of angle closure glaucoma. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Withdrawal Effects Abrupt discontinuation of chronically administered SSRIs used to treat chronic depressive disorders has been reported to result in the following symptoms: dysphoric mood, irritability, agitation, dizziness, sensory disturbances (e.g., paresthesias such as electric shock sensations), anxiety, confusion, headache, lethargy, emotional lability, insomnia and hypomania. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Possible Side Effects Most common side effects Tadalafil Dapoxetine Combination tablets are increased thirst and a light-headedness following sudden movements - this is natural, as blood moves into the genital areas. The common side effects include headache, dyspepsia, back pain, myalgia, nasal congestion, flushing, nausea, dizziness, diarrhoea, insomnia,fatigue and pain in limb. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets Overdose Single doses up to 500 mg of Tadalafil have been given to healthy subjects, and multiple daily doses up to 100 mg have been given to patients.
Adverse events were similar to those seen at lower doses. In cases of overdose, standard supportive measures should be adopted as required. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets Overdose No case of Dapoxetine overdose has been reported.
Discuss increased risk of NAION in patients with history of NAION. Patients should dapoxetine 60 mg tablets stop Tadalafil Dapoxetine tablets and seek prompt medical attention in the event of sudden decrease or loss of hearing. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Dapoxetine, a constituent of this medicine is only indicated in men with Premature Ejaculation who meet all the criteria listed listed earlier. Dapoxetine should not be prescribed to men who have not been diagnosed with Premature Ejaculation. Safety has not been established and there are no data on the ejaculation-delaying effects in men without Premature Ejaculation.
Before treatment initiation, a careful medical examination including history of orthostatic events should be performed by the physician. An orthostatic test should be performed before initiating therapy (blood pressure and pulse rate, supine and standing). In case of a history of documented or suspected orthostatic reaction, treatment with Tadalafil Dapoxetine tablets should be avoided. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Antidepressants, including SSRIs, increased the risk compared to placebo of suicidal thinking and suicidality in short-term studies in children and adolescents with Major Depressive Disorder and other psychiatric disorders. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24.
In clinical trials with Dapoxetine, a constituent of Tadalafil Dapoxetine tablets for the treatment of premature ejaculation, there was no clear indication of treatment-emergent suicidality in evaluation of possibly suicide-related adverse events. Patients should avoid operating hazardous machinery, should syncope or its prodromal symptoms such as dizziness or lightheadedness occur. The risk of adverse cardiovascular outcomes from syncope (cardiac syncope and syncope from other causes) is increased in patients with underlying structural cardiovascular disease. © Clearsky Pharmacy TadalafilDapoxetine Tablets to treat Erectile Dysfunction and Premature Ejaculation at the Same Time Tadalafil Dapoxetine Tablets - Warnings Patients should be advised not to use Tadalafil Dapoxetine tablets in combination with recreational drugs. Patients should be advised not to use Tadalafil Dapoxetine tablets in combination with alcohol. There were no unexpected adverse events in a clinical pharmacology study of Dapoxetine with daily doses up to 240 mg (two 120 mg doses given 3 hours apart).
| Medication | Common Side Effects | Less Common Side Effects | Serious Risks |
|---|---|---|---|
| Dapoxetine | Nausea, dizziness, headache | Insomnia, dry mouth | Suicidal thoughts, serotonin syndrome |
| Tadalafil | Headache, flushing, nasal congestion | Back pain, muscle aches | Priapism, sudden vision loss |
| Dapoxetine | Gastrointestinal discomfort | Fatigue | Allergic reactions |
| Tadalafil | Indigestion, visual disturbances | Light sensitivity | Cardiovascular events |
In general, symptoms of overdose with SSRIs include serotonin-mediated adverse reactions such as somnolence, gastrointestinal disturbances such as nausea and vomiting, tachycardia, tremor, agitation and dizziness. Due to high protein binding and large volume of distribution of Dapoxetine Hydrochloride, forced diuresis, dialysis, hemoperfusion and exchange transfusion are unlikely to be of benefit.