The condition can result from problems with messages being sent from your brain. ED can also result from problems with blood flow into your penis.
The metabolite is further metabolized to inactive compounds. Sildenafil is excreted as metabolites primarily in the feces (approximately 80% of administered oral dose) and to a lesser extent in the urine (approximately 13% of the administered oral dose). Both sildenafil and its active metabolite have terminal half-lives of about 4 hours. Sildenafil concentrations at 24 hours post a single 100 mg oral dose average 2 ng/mL (compared to peak plasma concentrations of approximately 440 ng/mL). While similar pharmacokinetic parameters were observed in healthy volunteers and patients with erectile dysfunction, the average steady-state concentrations were 20% to 50% higher and Cmin levels doubled in patients with PAH compared to healthy volunteers.
Affected cytochrome P450 isoenzymes: CYP3A4 and CYP2C9Sildenafil is metabolized principally by the hepatic cytochrome P450 (CYP) 3A4; CYP2C9 is also involved to a lesser degree. Dosage reductions are recommended for patients receiving potent cytochrome CYP3A4 inhibitors. Sildenafil is rapidly absorbed after oral administration, with a mean absolute bioavailability of about 41% (25% to 63%). Its pharmacokinetics are dose-proportional over the recommended dose range. Maximum observed plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) of oral dosing in the fasted state. Viagra works to treat ED by helping you get and maintain an erection. The drug does this by improving blood flow into your penis when you’re sexually aroused. Viagra is a type of drug called a phosphodiesterase type 5 (PDE5) inhibitor.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra | 100mg | 180 + 6 Pills | 436.79€ 415.99€ | |
| Viagra Generic | 200mg | 90 + 6 Pills | 170.79€ 162.66€ | |
| Kamagra Polo | 100mg | 32 Pills | 125.88€ 119.89€ | |
| Viagra Generic | 100mg | 90 + 6 Pills | 129.02€ 122.88€ | |
| Viagra Generic | 200mg | 270 + 10 Pills | 379.76€ 361.68€ | |
| Viagra Generic | 50mg | 120 + 6 Pills | 129.64€ 123.47€ | |
| Kamagra Polo | 100mg | 180 + 8 Pills | 446.52€ 425.26€ | |
| Kamagra Oral Jelly | 100mg | 63 + 7 Sachets | 224.18€ 213.50€ | |
| Kamagra Oral Jelly | 100mg | 10 Sachets | 54.55€ 51.95€ | |
| Kamagra Polo | 100mg | 84 + 4 Pills | 244.49€ 232.85€ | |
| Viagra Generic | 25mg | 30 + 4 Pills | 47.97€ 45.69€ | |
| Kamagra Soft Tabs | 100mg | 12 Pills | 57.55€ 54.81€ |
It works by inhibiting (blocking) the action of an enzyme called PDE5. (An enzyme is a protein that helps chemical reactions to happen inside your body.) Usually, an erection goes away when PDE5 breaks down the cyclic GMP in your penis.
Oral Suspension (Liqrev):When sildenafil is taken with a high fat meal, the rate of absorption is reduced, with a mean delay in Tmax of 60 minutes and a mean reduction in Cmax of 53%; the extent of absorption (AUC) is increased by 11%.Oral tablets and oral powder for suspension (Revatio, Viagra):When sildenafil is taken with a high fat meal, the rate of absorption is reduced, with a mean delay in Tmax of 60 minutes and a mean reduction in Cmax of 29%. A 10 mg IV dose is predicted to provide a pharmacological effect of sildenafil and its N-desmethyl metabolite equivalent to that of a 20 mg PO dose. Limited data do not report a clear association with the use of sildenafil and major birth defects, miscarriage, or adverse maternal or fetal outcomes when sildenafil is used during pregnancy. No evidence of teratogenicity or embryofetal toxicity was observed in animal reproduction studies using sildenafil at doses 32- and 65-times the recommended human dose. There are risks to the mother and fetus from untreated pulmonary arterial hypertension.
Limited clinical data preclude a clear determination of the risk of sildenafil to an infant during breast-feeding. Data from a case report describe the presence of sildenafil and its active metabolite in human milk. There is insufficient information on the effects of sildenafil on the breast-fed infant and no information on the effects of sildenafil on milk production. Viagra is a medication used to treat erectile dysfunction by improving blood flow to the penis. The drug is available in different dosages. But Viagra blocks the action of PDE5, so it allows cyclic GMP to keep working for a longer period of time than usual. This action improves blood flow to your penis and helps you get and keep an erection. No, Viagra doesn’t directly increase your sex drive.
These messages cause certain chemicals to be released in your penis. One of these chemicals, called cyclic GMP, relaxes and widens certain blood vessels in your penis. Cyclic GMP also relaxes the muscles around the erectile tissue in your penis that’s called the corpus cavernosum. These actions allow blood to flow into the corpus cavernosum, which causes your penis to get hard and become erect. ED can occur if you have certain problems that affect your body’s ability to have an erection. And it doesn’t make you sexually aroused. However, some people find that if Viagra works to treat their erectile problem, it also increases their sexual confidence. And this may lead to an increased sex drive. Viagra may not work for everyone, and it may not work every time 200mg sildenafil citrate you take it.
The appropriate dose depends on factors like age, kidney or liver problems, and other medications being taken. While generally considered safe, Viagra can cause side effects, including headaches and low blood pressure. It can also interact negatively with other medications like nitrates. Viagra is a brand-name oral tablet prescribed for erectile dysfunction (ED). You’ll find key information about Viagra below.
Drug class: phosphodiesterase type 5 (PDE5) inhibitor In several clinical studies, Viagra was effective in treating erectile dysfunction (ED). In these studies, males who used the drug had an improved ability to have and keep erections during sexual activity. To learn more about Viagra’s effectiveness, see the “Viagra uses” section. Use of the term “male” in this article refers to sex assigned at birth. Viagra typically starts to work between 30 and 60 minutes after you take a dose of the drug. If you’re sexually aroused, Viagra should work to help you get or keep an erection within 30 minutes to 2 hours. But if you don’t get an erection within 4 hours after taking a dose, Viagra didn’t work for you this time. If the drug doesn’t work for you, you shouldn’t take another dose until at least 24 hours later. And talk with your doctor if you feel Viagra isn’t helping to treat your ED.
But Viagra itself doesn’t give you an erection. You’ll need to be sexually aroused in order for the drug to work. Viagra keeps working in your body for up to 5 hours. This means that if you’re aroused, you should still be able to get an erection up to 4 hours after taking a dose of Viagra. Even though Viagra keeps working in your body for several hours, your erection shouldn’t last this long.
In fact, in sildenafil tablet manforce 50 mg rare cases, Viagra can cause priapism (a long-lasting and sometimes painful erection). Priapism is a medical emergency that needs to be treated right away. If it’s not treated, the condition can damage the tissues in your penis and cause irreversible erectile dysfunction. If you have an erection that lasts longer than 4 hours, go to the nearest emergency room or call 911. Viagra may work faster if you take it on an empty stomach. They may recommend that you try a different medication for your ED. It’s important to remember that Viagra only works if you’re already sexually aroused.
Arousal may involve having sexual thoughts, looking at sexual images, masturbating, or engaging in foreplay. But if you feel anxious, nervous, depressed, or stressed, your body may not respond well to sexual stimulation. If this is the case, try to relax, make yourself comfortable, and take your time.
If Viagra is taken with food, especially with a high fat meal, it will take longer to start working. And in this case, it could even be less effective for you. Viagra is approved to treat erectile dysfunction (ED) in males. With ED, you have trouble getting and keeping an erection that’s firm enough to allow you to have sex. When you’re sexually aroused, your brain sends messages to your penis. In addition, if you drink alcohol, it’s best to avoid drinking a lot of it. This is because consuming large amounts of alcohol can make it more difficult to get an erection. If you’re having trouble getting an erection, even while using Viagra, talk with your doctor. Instead, it belongs to a group of drugs called phosphodiesterase type 5 (PDE5) inhibitors. Viagra works by blocking the action of a certain enzyme in your body. Since Viagra has been released onto the market, there have been a few reports of bleeding in people who have taken the drug. However, there’s no evidence that Viagra caused these bleeding problems. It’s not known if Viagra is safe for use in people with a bleeding problem. If you have any bleeding problems, talk with your doctor about whether Viagra is safe for you.
| Country | Approval Status | Regulatory Agency | Notes |
|---|---|---|---|
| USA | Approved | FDA | For ED and pulmonary hypertension |
| European Union | Approved | EMA | Similar indications |
| India | Approved | CDSCO | Generic versions available |
| Australia | Approved | TGA | Prescription required |
After taking a dose of Viagra, the drug’s level in your body will gradually decrease over a period of a few hours.
| Side Effect | Severity | Common Symptoms | Frequency |
|---|---|---|---|
| Headache | Mild to Moderate | Throbbing pain, sensation of pressure | Very common |
| Flushing | Mild | Skin redness, warmth | Common |
| Dyspepsia (Indigestion) | Mild | Burning sensation in stomach | Common |
| Visual disturbances | Mild to moderate | Blue tint, blurred vision | Less common |
| Priapism | Severe | Prolonged and painful erection | Rare |
You’ll have low levels of the drug in your body after about 4 hours. (And at this point, the drug won’t be working any longer.) But it can actually take about 24 hours for Viagra to be completely removed from your body. If you have other questions about how long Viagra works, talk with your doctor. Viagra can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Viagra.
These lists don’t include all possible side effects. For more information on the possible side effects of Viagra, talk with your doctor or pharmacist. They can give you tips on how to deal with any side effects that may be concerning or bothersome. Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to report to the FDA a side effect you’ve had with Viagra, you can do so through MedWatch. Mild side effects of Viagra can include:* mild and temporary vision changes, such as a blue tinge in your vision, blurred vision, and sensitivity to light Most of these side effects may go away within a few days or a couple of weeks.
| Brand Name | Manufacturer | Formulation Type | Typical Dosage | Notes |
|---|---|---|---|---|
| Viagra | Pfizer | Tablet | 25, 50, 100 mg | Most well-known brand |
| Revatio | Pfizer | Tablet | 20 mg | For pulmonary hypertension |
| Sildenafil Citrate | Various generic manufacturers | Tablet | 25, 50, 100 mg | Generic versions available |
| Kamagra | Ajanta Pharma | Oral Gel | 100 mg | Used off-label in some countries |
But if they become more severe or don’t go away, talk with your doctor or pharmacist. * This is a partial list of mild side effects from Viagra. To learn about other mild side effects, talk with your doctor or pharmacist, or view the drug’s prescribing information. Serious side effects from Viagra aren’t common, but they can occur. Call your doctor right away if you have serious side effects.